Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs).  Read more

Yogheswaran Gopalan, Ibrahim Lutfi Shuaib, Enrico Magosso, Mukhtar Alam Ansari, Mohd Rizal Abu Bakar, Jia Woei Wong, Nurzalina Abdul Karim Khan, Wei Chuen Liong, et al.

Publications: Stroke
Date: April 2014
Vitamin E consists of tocopherols and tocotrienols, in which α-tocotrienol is the most potent neuroprotective form that is also effective in protecting against stroke in rodents. Read more

Cameron Rink, Greg Christoforidis, Savita Khanna, Laura Peterson, Yojan Patel, Suchin Khanna, Amir Abduljalil, Okan Irfanoglu, Raghu Machiraju, Valerie K Bergdall, Chandan K Sen

Publications: Journal of Cerebral Blood Flow and Metabolism
Date: Nov 2011
Vascular dementia (VaD) is a serious global health issue and type 2 diabetes mellitus (T2DM) patients are at higher risk. Palm oil tocotrienol-rich fraction (TRF) exhibits neuroprotective properties; however, its effect on VaD is not reported. Hence, we evaluated TRF effectiveness in T2DM-induced VaD rats.   Read more

Sohrab A. Shaikh, Rajavel Varatharajan and Arunachalam Muthuraman

Publications: International Journal of Molecular Sciences 
Date: Nov 2022
To define whether tocotrienol (T-3) improves cognitive deficit during aging, effect of T-3 on learning and memory functions of aged rats was assessed. It was found that T-3 markedly counteracts the decline in learning and memory function in aged rats.  Read more

Nozomi Kaneai, Kazumi Sumitani, Koji Fukui, Taisuke Koike, Hirokatsu Takatsu, Shiro Urano

Publications: Journal of Clinical Biochemistry and Nutrition
Date: Nov 2016
α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration.  Read more

Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chan, Sashwati Roy, Savita Khanna and Chandan K. Sen

Publications: Stroke
Date: June 2011
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Powerful Antioxidants
Supports Liver Health
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