Anti Inflammatory Properties

Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that are comparable to or exceed those of tocopherols (Toc).   Read more

Zaida Zainal, Huzwah Khaza’ai, Ammu Kutty, Radhakrishnan, Sui Kiat Chang

Publications: Food Research International Date: June 2022

Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases.   Read more

Marco Malavolta, Elisa Pierpaoli, Robertina Giacconi, Andrea Basso, Maurizio Cardelli, Francesco Piacenza, and Mauro Provinciali

Publications: Biological Procedures Online Date: Nov 2018

Tocotrienol attenuates oxidative–nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy

Diabetic neuropathic pain, an important microvascular complication in diabetes mellitus, is recognised as one of the most difficult types of pain to treat.   Read more

Anurag Kuhad, Kanwaljit Chopra

Publications: Neuropharmacology Date: June 2009

Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells

Tocotrienol-rich fraction (TRF) of palm oil has been shown to possess potent antioxidant, anticancer, and cholesterol lowering activities.  Read more

Shu-Jing Wu, Po-Len Liu, Lean-Teik Ng

Publications: Molecular Nutrition and Food Research
Date: Feb 2022

Tocotrienol-Rich Fractions Offer Potential to Suppress Pulmonary Fibrosis Progression

Although pulmonary fibrosis (PF) is considered a rare disease, the incidence thereof has increased steadily in recent years, while a safe and effective cure remains beyond reach. In this study, the potential of tocotrienol-rich fractions (TRF) and carotene to alleviate PF was explored.  Read more

Yifei Lu, Yihan Zhang, Dengfeng Xu, Yuanyuan Wang, Da Pan, Pei Wang, Jiayue Xia, Shiyu Yin, Wang Liao, Shaokang Wang and Guiju Sun

Publications: International Journal of Molecular Sciences
Date: Nov 2022

Therapeutic effects of intranasal tocotrienol-rich fraction on rhinitis symptoms in platelet-activating factor induced allergic rhinitis

Platelet-activating factor (PAF) has been suggested to be a potent inflammatory mediator in Allergic rhinitis (AR) pathogenesis. Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is known as a potential therapeutic agent for airway allergic inflammation.  Read more

Cheryl Wei Ling Teo, Stephanie Jia Ying Png, Yee Wei Ung, Wei Ney Yap

Publications: Allergy, Asthma & Clinical Immunology
Date: June 2022

Tocotrienol (unsaturated vitamin E) suppresses degranulation of mast cells and reduces allergic dermatitis in mice

In this study, we examined whether tocotrienol (T3) reduces allergic dermatitis in mice and suppresses degranulation of mast cells. First, allergic dermatitis was examined in the atopic dermatitis model NC/Nga mouse. Read more

Tsuyoshi Tsuduki, Keiko Kuriyama, Kiyotaka Nakagawa, Teruo Miyazawa

Publications: Journal of Oleo Science
Date: April 2013

Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers

Vitamin E is an essential fat-soluble vitamin that has been shown to induce favorable effects on animal and human immune systems. The objective of this study was to assess the effects of tocotrienol-rich fraction (TRF) supplementation on immune response following tetanus toxoid (TT) vaccine challenge in healthy female volunteers.  Read more

D Mahalingam, A K Radhakrishnan, Z Amom, N Ibrahim & K Nesaretnam

Publications: European Journal of Clinical Nutrition
Date: Sept 2010

Dietary Supplementation with Tocotrienols Enhances Immune Function in C57BL/6 Mice

α-Tocopherol (α-Toc) enhances T cell function, whereas little is known in this regard for tocotrienols (T3), the less-known members of the vitamin E family. We pair-fed young (4 mo) and old (23 mo) C57BL/6 mice 0.1% Tocomin 50%, a mixture of T3 and α-Toc or a control diet containing an equal amount of α-Toc for 6 wk. Read more

Zhihong Ren, Munkyong Pae, Maria Carlota Dao, Donald Smith, Simin Nikbin Meydani, Dayong Wu

Publications: Journal of Nutrition
Date: July 2010

Other Benefits of Vitamin E Tocotrienols

Powerful Antioxidants
Neuroprotection
Supports Liver Health
Supports Skin Health
Supports Heart Health